Ethanol → 3-Chloro-6-(3,5-dimethyl-4-amino-1-pyrazolyl)-pyridazine
反応式
[Cl:1][C:2]1[N:3]=[N:4][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([N:14]3C(=O)C4=CC=CC=C4C3=O)[C:10]([CH3:25])=[N:9]2)=[CH:6][CH:7]=1.C(O)C.O.NN>O>[Cl:1][C:2]1[N:3]=[N:4][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([NH2:14])[C:10]([CH3:25])=[N:9]2)=[CH:6][CH:7]=1参加物
5
実験手順
A mixture of 3.54 g (0.01 moles) of 3-chloro-6-(3,5-dimethyl-4-phthalimido-1-pyrazolyl)-pyridazine, 40 ml of ethanol and 1.08 g (0.01 moles) of 98% hydrazine hydrate is heated to reflux for 3 hours and the mixture is poured into 100 ml of water. After cooling the precipitated crystals are filtered, washed with water, triturated with 10 ml of hot ethanol, filtered and dried. Yield: 1.8 g (81%); m.p. 165°-168° C.
後処理
- temperatureis heated
- temperatureto reflux for 3 hours
- temperatureAfter cooling the precipitated crystals
- filtrationare filtered
- washwashed with water
- customtriturated with 10 ml of hot ethanol
- filtrationfiltered
- customdried
出典と根拠
- ORDレコード
- ord-2de05f19ff944bc5b5923558451fcc83
- 出典データセット
- uspto-grants-1980_09
- 特許番号
- US04224325
反応ノート
読み込み中…