Hydrazine hydrate (1:1) → 3(2H)-Pyridazinone, 6-(3,5-dimethyl-1H-pyrazol-1-yl)-, hydrazone

HRID 27895

反応式

HRID 27895 の反応式
Cl[C:2]1[N:3]=[N:4][C:5]([N:8]2[C:12]([CH3:13])=[CH:11][C:10]([CH3:14])=[N:9]2)=[CH:6][CH:7]=1.O.[NH2:16][NH2:17].O1CCOCC1>O>[NH:16]([C:2]1[N:3]=[N:4][C:5]([N:8]2[C:12]([CH3:13])=[CH:11][C:10]([CH3:14])=[N:9]2)=[CH:6][CH:7]=1)[NH2:17]

参加物

5

反応物 3

HCID 24654Hydrazine hydrate (1:1)HCID 312751,4-DioxaneHCID 3210733-Chloro-6-(3,5-dimethylpyrazol-1-yl)pyridazine

生成物 1

HCID 30539723(2H)-Pyridazinone, 6-(3,5-dimethyl-1H-pyrazol-1-yl)-, hydrazone

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 34.2 g. of 3-chloro-6-(3,5-dimethyl-1-pyrazolyl)-pyridazine, 100 ml of 72% hydrazine hydrate and 200 ml of dioxane is stirred at 90°-95° C. for 14 hours, then the mixture is poured into 1 liter of water, extracted three times with 150 ml of chloroform each, and the combined organic phases are dried over magnesium sulphate. After evaporation of the solvent, the residue is recrystallized from isopropanol. Yield: 27 g /80%/; m.p.: 142°-143° C.

後処理

  1. additionA mixture of 34.2 g
  2. extractionextracted three times with 150 ml of chloroform each, and the combined organic phases
  3. dry with materialare dried over magnesium sulphate
  4. customAfter evaporation of the solvent
  5. customthe residue is recrystallized from isopropanol

出典と根拠

ORDレコード
ord-4ac82b5535e94a9f90c855027f1f8454
出典データセット
uspto-grants-1980_09
特許番号
US04224325

関連ノート

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