Triethylamine → 5-phenyl-penta-2,4-dienoic acid-N-(2-carboxy-4-fluoro-phenyl)-amide

HRID 279204

反応式

HRID 279204 の反応式
[C:1]1([CH:7]=[CH:8][CH:9]=[CH:10][C:11](Cl)=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:14][C:15]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:16]=1[C:17]([OH:19])=[O:18].C(N(CC)CC)C>O1CCCC1>[C:17]([C:16]1[CH:20]=[C:21]([F:24])[CH:22]=[CH:23][C:15]=1[NH:14][C:11](=[O:12])[CH:10]=[CH:9][CH:8]=[CH:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)([OH:19])=[O:18]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 1014122-Amino-5-fluorobenzoic acidHCID 30848092,4-Pentadienoyl chloride, 5-phenyl-

生成物 1

HCID 739936225-phenyl-penta-2,4-dienoic acid-N-(2-carboxy-4-fluoro-phenyl)-amide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Prepared analogously to Example 31 from 5-phenyl-penta-2,4-dienoic acid chloride and 2-amino-5-fluoro-benzoic acid in tetrahydrofuran with the addition of triethylamine.

出典と根拠

ORDレコード
ord-3b01083c5a344918b84c9a2c5bceb051
出典データセット
uspto-grants-2002_03
特許番号
US06362210B1

関連ノート

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