7-Benzyloxy-6-methoxy-4-phenoxyquinazoline → 7-Hydroxy-6-methoxy-4-phenoxyquinazoline

HRID 279516ノート

反応式

HRID 279516 の反応式
C([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([O:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:14][CH:15]=[N:16]2)=[CH:11][C:10]=1[O:26][CH3:27])C1C=CC=CC=1>C(O)(C(F)(F)F)=O>[OH:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([O:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:14][CH:15]=[N:16]2)=[CH:11][C:10]=1[O:26][CH3:27]

参加物

3

反応物 1

HCID 218748147-Benzyloxy-6-methoxy-4-phenoxyquinazoline

生成物 1

HCID 1354961377-Hydroxy-6-methoxy-4-phenoxyquinazoline収率 89%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

7-Benzyloxy-6-methoxy-4-phenoxyquinazoline (160 mg, 0.44 mmol) in TFA (3 ml) was heated at reflux for 30 minutes. The solvent was removed by evaporation and the residue treated with aqueous sodium hydrogen carbonate solution. The precipitated product was collected by filtration, washed with water and dried to give 7-hydroxy-6-methoxy-4-phenoxyquinazoline (105 mg, 88%).

後処理

  1. temperatureat reflux for 30 minutes
  2. customThe solvent was removed by evaporation
  3. additionthe residue treated with aqueous sodium hydrogen carbonate solution
  4. filtrationThe precipitated product was collected by filtration
  5. washwashed with water
  6. customdried

出典と根拠

ORDレコード
ord-c507767c98c74063ab746d75277fb41b
出典データセット
uspto-grants-2002_03
特許番号
US06362336B1

反応ノート

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