Formaldehyde → (1-methyl-1H-1,3-benzodiazol-2-yl)methanol

HRID 279566

反応式

HRID 279566 の反応式
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=[CH:3]1.[CH2:11]=[O:12]>>[OH:12][CH2:11][C:3]1[N:2]([CH3:1])[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=1

参加物

3

反応物 2

HCID 712Formaldehyde2 回HCID 958901H-Benzimidazole, 1-methyl-

生成物 1

HCID 344177(1-methyl-1H-1,3-benzodiazol-2-yl)methanol収率 45%

実験手順

A solution of 1-methylbenzimidazole (2.5 g, 19 mmol), (J. Chem. Soc. 1929, 2820-2828), and paraformaldehyde (2 g) was heated at 60° C. for 30 minutes. Further paraformaldehyde (1 g) was added and heating continued for 2 hours. The mixture was allowed to cool and was purified by column chromatography eluting with methylene chloride, followed by methylene chloride/methanol (95/5) to give 2-hydroxymethyl-1-methylbenzimidazole (1.34 g, 45%).

後処理

  1. temperatureheating
  2. temperatureto cool
  3. customwas purified by column chromatography
  4. washeluting with methylene chloride

出典と根拠

ORDレコード
ord-ae28e1fdb53b47df8b8213ec6d1ac247
出典データセット
uspto-grants-2002_03
特許番号
US06362336B1

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