Methyl iodide → Ethyl 2-methoxyisonicotinate
反応式
[OH:1][C:2]1[CH:7]=[C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH:5]=[CH:4][N:3]=1.[CH3:13]I>C1(C)C=CC=CC=1.C(=O)([O-])[O-].[Ag+].[Ag+]>[CH3:13][O:1][C:2]1[CH:7]=[C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH:5]=[CH:4][N:3]=1参加物
5
実験手順
A mixture of ethyl 2-hydroxy-pyridine-4-carboxylate (1.0 g, 6 mmol), (Chem. Abs. 1957, 8740c), methyl iodide (1 ml) and silver(I)carbonate (1.64 g) in toluene (20 ml) was heated at reflux for 2 hours. The mixture was allowed to cool and the insolubles removed by filtration through diatomaceous earth and the pad was washed through with ethyl acetate. The filtrate was washed with water, dried (MgSO4) and the solvent removed by evaporation to give ethyl 2-methoxy-pyridine-4-carboxylate (0.93 g, 86%) as a yellow oil.
後処理
- temperaturewas heated
- temperatureat reflux for 2 hours
- temperatureto cool
- customthe insolubles removed by filtration through diatomaceous earth
- washthe pad was washed through with ethyl acetate
- washThe filtrate was washed with water
- dry with materialdried (MgSO4)
- customthe solvent removed by evaporation
出典と根拠
- ORDレコード
- ord-3ca27f6c0bb74ff081f35892abaa3ae6
- 出典データセット
- uspto-grants-2002_03
- 特許番号
- US06362336B1
反応ノート
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