HCID 22624891、化合物 → 2-(Pyridin-3-yloxy)ethan-1-ol

HRID 279630ノート

反応式

HRID 279630 の反応式
O1CCCCC1[O:7][CH2:8][CH2:9][O:10][C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1>C(O)(=O)C.C1COCC1.O>[OH:7][CH2:8][CH2:9][O:10][C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1

参加物

5

反応物 1

HCID 22624891HCID 22624891、化合物

生成物 1

HCID 219089972-(Pyridin-3-yloxy)ethan-1-ol収率 86%

試薬・触媒・溶媒 3

HCID 176Acetic Acid溶媒HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 3-(2-(tetrahydropyran-2-yloxy)ethoxy)pyridine (1.54 g, 7 mmol) in acetic acid (8 ml), THF (4 ml) and water (2 ml) was heated at 50° C. for 4 hours. The volatiles were removed by evaporation and the residue azeotroped with toluene to give 3-(2-hydroxyethoxy)pyridine (820 mg, 86%) as an off-white solid.

後処理

  1. customThe volatiles were removed by evaporation
  2. customthe residue azeotroped with toluene

出典と根拠

ORDレコード
ord-27d37db75bc147aaac8aa4d41bb8802f
出典データセット
uspto-grants-2002_03
特許番号
US06362336B1

反応ノート

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