Trichloroacetic Acid → 2,2,2-Trichloro-1,1-di(2,3,4,5,6-pentafluorophenyl)-1-ethanol

HRID 279692

反応式

HRID 279692 の反応式
[F:1][C:2]1[C:7]([C:8](=[O:20])[C:9]2[C:14]([F:15])=[C:13]([F:16])[C:12]([F:17])=[C:11]([F:18])[C:10]=2[F:19])=[C:6]([F:21])[C:5]([F:22])=[C:4]([F:23])[C:3]=1[F:24].[Cl:25][C:26]([Cl:31])([Cl:30])C(O)=O.FF.C([O-])(=O)C=C>CO.CN(C)P(N(C)C)(N(C)C)=O>[Cl:25][C:26]([Cl:31])([Cl:30])[C:8]([C:9]1[C:10]([F:19])=[C:11]([F:18])[C:12]([F:17])=[C:13]([F:16])[C:14]=1[F:15])([C:7]1[C:2]([F:1])=[C:3]([F:24])[C:4]([F:23])=[C:5]([F:22])[C:6]=1[F:21])[OH:20]

参加物

7

反応物 4

HCID 6421Trichloroacetic AcidHCID 24524FluorineHCID 25188AcrylateHCID 70068Decafluorobenzophenone

生成物 1

HCID 226252562,2,2-Trichloro-1,1-di(2,3,4,5,6-pentafluorophenyl)-1-ethanol

試薬・触媒・溶媒 2

HCID 887Methanol溶媒2 回HCID 12679Hexamethylphosphoramide溶媒

反応条件

温度
0 °C

実験手順

A mixture of 4.9 g of decafluorobenzophenone and 2.7 g of trichloroacetic acid was added to 15 mL of hexamethylphosphoramide. The stirred reaction mixture was maintained at about 0° C. for about 2 hours and then allowed to warm to room temperature and continue stirring at ambient temperature for the next 15 hours. The reaction mixture was characterized by GC and fluorine NMR to show a conversion of approximately 20% to the desired carbinol. This carbinol can be converted to the corresponding acrylate by methods previously described (cf. Example 24).

後処理

  1. customThe stirred reaction mixture
  2. temperatureto warm to room temperature

出典と根拠

ORDレコード
ord-a5294303fdcc4562a1bcd0a97cbe79d7
出典データセット
uspto-grants-2002_03
特許番号
US06362379B1

関連ノート

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