Sodium Bicarbonate → 4-Methyl-5-propionyloxazole
反応式
CON(C)[C:4]([C:6]1[O:10][CH:9]=[N:8][C:7]=1[CH3:11])=[O:5].[CH2:13]([Mg]Br)[CH3:14].C(=O)([O-])O.[Na+]>O1CCCC1>[CH3:11][C:7]1[N:8]=[CH:9][O:10][C:6]=1[C:4](=[O:5])[CH2:13][CH3:14]参加物
5
実験手順
N-Methoxy-N-methyl-4-methyl-5-oxazolecarboxamide (5 g) in dry tetrahydrofuran at -40° C. was stirred under a nitrogen atmosphere and ethylmagnesium bromide (1M solution in tetrahydrofuran, 35 ml) was added dropwise. After 30 minutes the mixture was allowed to warm to room temperature and then stirred for a further 1 hour. Aqueous sodium hydrogen carbonate was added, the organic layer was separated and the aqueous layer was extracted with diethylether. The material thus obtained was purified by flash chromatography to yield a pale yellow liquid which solidified on cooling.
後処理
- customthe organic layer was separated
- extractionthe aqueous layer was extracted with diethylether
- customThe material thus obtained
- customwas purified by flash chromatography
- customto yield a pale yellow liquid which
- temperatureon cooling
出典と根拠
- ORDレコード
- ord-1bc1f72b809c473ca26027a1470cdec4
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05731335
反応ノート
読み込み中…