Sodium Bicarbonate → 4-Methyl-5-propionyloxazole

HRID 2797

反応式

HRID 2797 の反応式
CON(C)[C:4]([C:6]1[O:10][CH:9]=[N:8][C:7]=1[CH3:11])=[O:5].[CH2:13]([Mg]Br)[CH3:14].C(=O)([O-])O.[Na+]>O1CCCC1>[CH3:11][C:7]1[N:8]=[CH:9][O:10][C:6]=1[C:4](=[O:5])[CH2:13][CH3:14]

参加物

5

反応物 3

HCID 516892Sodium BicarbonateHCID 18925369N-Methoxy-N,4-dimethyloxazole-5-carboxamideHCID 178418443HCID 178418443、化合物

生成物 1

HCID 189363294-Methyl-5-propionyloxazole

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

N-Methoxy-N-methyl-4-methyl-5-oxazolecarboxamide (5 g) in dry tetrahydrofuran at -40° C. was stirred under a nitrogen atmosphere and ethylmagnesium bromide (1M solution in tetrahydrofuran, 35 ml) was added dropwise. After 30 minutes the mixture was allowed to warm to room temperature and then stirred for a further 1 hour. Aqueous sodium hydrogen carbonate was added, the organic layer was separated and the aqueous layer was extracted with diethylether. The material thus obtained was purified by flash chromatography to yield a pale yellow liquid which solidified on cooling.

後処理

  1. customthe organic layer was separated
  2. extractionthe aqueous layer was extracted with diethylether
  3. customThe material thus obtained
  4. customwas purified by flash chromatography
  5. customto yield a pale yellow liquid which
  6. temperatureon cooling

出典と根拠

ORDレコード
ord-1bc1f72b809c473ca26027a1470cdec4
出典データセット
uspto-grants-1998_03
特許番号
US05731335

関連ノート

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