2-Amino-4,6-dimethyl pyrimidine → 2-(Dichloromethyl)-N-[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]benzenesulfonamide

HRID 279748

反応式

HRID 279748 の反応式
[Cl:1][CH:2]([Cl:15])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9]([N:12]=[C:13]=[O:14])(=[O:11])=[O:10].[NH2:16][C:17]1[N:22]=[C:21]([CH3:23])[CH:20]=[C:19]([CH3:24])[N:18]=1>C(#N)C>[Cl:15][CH:2]([Cl:1])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9]([NH:12][C:13]([NH:16][C:17]1[N:22]=[C:21]([CH3:23])[CH:20]=[C:19]([CH3:24])[N:18]=1)=[O:14])(=[O:11])=[O:10]

参加物

4

反応物 2

HCID 130212-Amino-4,6-dimethyl pyrimidineHCID 201527002-(Dichloromethyl)benzenesulfonyl isocyanate

生成物 1

HCID 133646202-(Dichloromethyl)-N-[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]benzenesulfonamide

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

2-(Dichloromethyl)benzenesulfonyl isocyanate, prepared from 10 mmol of sulfonamide as described in the synthesis of Example 1, was treated with acetonitrile and 2-amino-4,6-dimethylpyrimidine (1.23 g). The mixture was stirred at room temperature for 18 hrs, cooled, and filtered to provide 1.08 g of white solid, mp 195°-197° (Dec).

後処理

  1. customas described in the synthesis of Example 1
  2. temperaturecooled
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-56fe6e3812b54c2bbf4c174bee1c74b2
出典データセット
uspto-grants-1986_05
特許番号
US04586952

関連ノート

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