Chlorotrimethylsilane → 4-Methyl-2-trimethylsilylthiazole
反応式
C([Li])CCC.[CH3:6][C:7]1[N:8]=[CH:9][S:10][CH:11]=1.[CH3:12][Si:13](Cl)([CH3:15])[CH3:14]>C(OCC)C>[CH3:6][C:7]1[N:8]=[C:9]([Si:13]([CH3:15])([CH3:14])[CH3:12])[S:10][CH:11]=1参加物
5
実験手順
n-Butyllithium (2.5M solution in hexane, 1.1 equivalents) was added dropwise to a solution of 4-methylthiazole (1.0 equivalent) in dry diethyl ether at -70° C. under an atmosphere of dry nitrogen. After 30 minutes, trimethylsilylchloride (1.0 equivalent) was added dropwise. The mixture was allowed to warm to room temperature and was then quenched by the addition of saturated aqueous sodium hydrogen carbonate. Work-up in the normal fashion and vacuum distillation then gave the title compound. B.p. 42° C. at 1 mmHg.
後処理
- customwas then quenched by the addition of saturated aqueous sodium hydrogen carbonate
- distillationWork-up in the normal fashion and vacuum distillation
出典と根拠
- ORDレコード
- ord-5a7b382c7d5a4739a7806a3eb2f4a308
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05731335
反応ノート
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