Chlorotrimethylsilane → 4-Methyl-2-trimethylsilylthiazole

HRID 2798

反応式

HRID 2798 の反応式
C([Li])CCC.[CH3:6][C:7]1[N:8]=[CH:9][S:10][CH:11]=1.[CH3:12][Si:13](Cl)([CH3:15])[CH3:14]>C(OCC)C>[CH3:6][C:7]1[N:8]=[C:9]([Si:13]([CH3:15])([CH3:14])[CH3:12])[S:10][CH:11]=1

参加物

5

反応物 3

HCID 6397ChlorotrimethylsilaneHCID 127484-MethylthiazoleHCID 178418339Butyllithium

生成物 1

HCID 116583544-Methyl-2-trimethylsilylthiazole

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

n-Butyllithium (2.5M solution in hexane, 1.1 equivalents) was added dropwise to a solution of 4-methylthiazole (1.0 equivalent) in dry diethyl ether at -70° C. under an atmosphere of dry nitrogen. After 30 minutes, trimethylsilylchloride (1.0 equivalent) was added dropwise. The mixture was allowed to warm to room temperature and was then quenched by the addition of saturated aqueous sodium hydrogen carbonate. Work-up in the normal fashion and vacuum distillation then gave the title compound. B.p. 42° C. at 1 mmHg.

後処理

  1. customwas then quenched by the addition of saturated aqueous sodium hydrogen carbonate
  2. distillationWork-up in the normal fashion and vacuum distillation

出典と根拠

ORDレコード
ord-5a7b382c7d5a4739a7806a3eb2f4a308
出典データセット
uspto-grants-1998_03
特許番号
US05731335

関連ノート

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