1H-Imidazole-4,5-dicarboxylic acid, 4,5-dimethyl ester → 1H-Imidazole-4,5-dimethanol

HRID 279846

反応式

HRID 279846 の反応式
[NH:1]1[C:5]([C:6](OC)=[O:7])=[C:4]([C:10](OC)=[O:11])[N:3]=[CH:2]1>O1CCCC1>[OH:7][CH2:6][C:5]1[N:1]=[CH:2][NH:3][C:4]=1[CH2:10][OH:11]

参加物

3

反応物 1

HCID 768101H-Imidazole-4,5-dicarboxylic acid, 4,5-dimethyl ester

生成物 1

HCID 5736291H-Imidazole-4,5-dimethanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Reflux dimethyl 4,5 imidazole dicarboxylate (1.8 g) in THF (tetrahydrofuran) with 2.5 equivalents of LAH lithium aluminum hydride). Neutralize with NH4Cl solution and filter. Concentrate the filtrate under vacumm and extract the product with ethanol. Remove the solvent, filtrate through alumina using a THF solvent to give the title compound.

後処理

  1. filtrationNeutralize with NH4Cl solution and filter
  2. concentrationConcentrate the filtrate under vacumm
  3. extractionextract the product with ethanol
  4. customRemove the solvent, filtrate through alumina using a THF solvent

出典と根拠

ORDレコード
ord-12483586f11b49f08bb683b241c74f50
出典データセット
uspto-grants-1986_05
特許番号
US04587241

関連ノート

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