Dimethyl Sulfoxide → 2-(Allyloxy)-4-methyl-1-nitrobenzene

HRID 279889

反応式

HRID 279889 の反応式
[OH-].[Na+].[CH3:3][C:4]1[CH:5]=[C:6]([OH:13])[C:7]([N+:10]([O-:12])=[O:11])=[CH:8][CH:9]=1.CS(C)=O.Cl[CH2:19][CH:20]=[CH2:21]>O>[CH2:21]([O:13][C:6]1[C:7]([N+:10]([O-:12])=[O:11])=[CH:8][CH:9]=[C:4]([CH3:3])[CH:5]=1)[CH:20]=[CH2:19]

参加物

6

反応物 4

HCID 679Dimethyl SulfoxideHCID 7850Allyl chlorideHCID 127886-Nitro-m-cresolHCID 14798Sodium Hydroxide

生成物 1

HCID 135756662-(Allyloxy)-4-methyl-1-nitrobenzene

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

A solution of 26.1 g of sodium hydroxide in 50 ml of water was added drop-by-drop over 5 minutes to a stirred mixture of 100 g of 3-methyl-6-nitrophenol, 400 ml of dimethylsulfoxide (DMSO) and 53.6 g of 3-chloro-1-propene initially at room temperature. The temperature of the mixture rose to 43° C. The mixture was heated at 90°-110° C. for two hours, poured into water and filtered, to give 1-(2-propenyloxy)-3-methyl-6-nitrobenzene (1A), as a light yellow solid, m.p.: 30°-32° C.

後処理

  1. customrose to 43° C
  2. temperatureThe mixture was heated at 90°-110° C. for two hours
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-9fcceda783364ae6b10c97d4816dff28
出典データセット
uspto-grants-1986_05
特許番号
US04587259

関連ノート

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