Sodium Hydroxide → 5-(4-Carboxybuta-1,3-dienyl)-imidazo[1,5-a]pyridine
反応式
C([O:3][C:4]([CH:6]=[CH:7][CH:8]=[CH:9][C:10]1[N:15]2[CH:16]=[N:17][CH:18]=[C:14]2[CH:13]=[CH:12][CH:11]=1)=[O:5])C.[OH-].[Na+]>CO>[C:4]([CH:6]=[CH:7][CH:8]=[CH:9][C:10]1[N:15]2[CH:16]=[N:17][CH:18]=[C:14]2[CH:13]=[CH:12][CH:11]=1)([OH:5])=[O:3]参加物
4
実験手順
To a solution of 200 mg of 5-(4-ethoxycarbonylbuta-1,3-dienyl)imidazo[1,5-a]pyridine in 20 ml of methanol is added 4 ml of 1N sodium hydroxide. The reaction mixture is stirred at room temperature for 18 hours. The methanol is evaporated under reduced pressure and the residue diluted with 20 ml of water and the solution is adjusted to pH 5 with hydrochloric acid. The precipitate is collected to give 5-(4-carboxybuta-1,3-dienyl)-imidazo[1,5-a]pyridine, melting at 243°-245°.
後処理
- customThe methanol is evaporated under reduced pressure
- additionthe residue diluted with 20 ml of water
- customThe precipitate is collected
出典と根拠
- ORDレコード
- ord-7e00622a39854c5db365d0fb36351fff
- 出典データセット
- uspto-grants-1986_05
- 特許番号
- US04588732
反応ノート
読み込み中…