2-Amino-1-(3-fluorophenyl)ethan-1-ol → HCID 23322168、化合物

HRID 280305

反応式

HRID 280305 の反応式
Cl[C:2]1[CH:3]=[C:4](C(O)CN)[CH:5]=[CH:6][CH:7]=1.[F:12][C:13]1[CH:14]=[C:15]([CH:19]([OH:22])[CH2:20][NH2:21])[CH:16]=[CH:17][CH:18]=1.[C:23](O)(=O)/[CH:24]=[CH:25]/[C:26](O)=O>>[CH3:23][C:24]1[CH:3]=[CH:2][C:7]([CH2:6][CH:5]([NH:21][CH2:20][CH:19]([OH:22])[C:15]2[CH:16]=[CH:17][CH:18]=[C:13]([F:12])[CH:14]=2)[CH3:4])=[CH:26][CH:25]=1

参加物

4

反応物 3

HCID 358002-Amino-1-(3-fluorophenyl)ethan-1-olHCID 444972Fumaric AcidHCID 37516012-Amino-1-(3-chlorophenyl)ethan-1-ol

生成物 1

HCID 23322168HCID 23322168、化合物

実験手順

The title compound was prepared in the manner described in Example 3 replacing 2-(3-chlorophenyl)-2-hydroxyethanamine with 2-(3-fluorophenyl)-2-hydroxyethanamine. The chromatographed material was treated with methanolic fumaric acid and the derived salt recrystallised from ethyl acetate to give the title compound (fumarate), mp 58-83, as a 52-48 mixture of diastereoisomers.

後処理

  1. customThe title compound was prepared in the manner
  2. customthe derived salt recrystallised from ethyl acetate

出典と根拠

ORDレコード
ord-cae322d37bd94ec9aae0e1baf9fe6a28
出典データセット
uspto-grants-1986_05
特許番号
US04588749

関連ノート

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