2-(3-Chlorophenyl)-2-oxoacetaldehyde → N-(3-(4-Methylphenyl)-1,1-dimethylpropyl)-2-hydroxy-2-(3-chlorophenyl)ethanamine

HRID 280316

反応式

HRID 280316 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]([CH:10]=O)=[O:9])[CH:5]=[CH:6][CH:7]=1.[CH3:12][C:13]1[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][C:21]([CH3:24])([CH3:23])[NH2:22])=[CH:15][CH:14]=1>>[CH3:12][C:13]1[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][C:21]([NH:22][CH2:10][CH:8]([OH:9])[C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)([CH3:23])[CH3:24])=[CH:15][CH:14]=1

参加物

3

反応物 2

HCID 124638932-(3-Chlorophenyl)-2-oxoacetaldehydeHCID 233221672-Methyl-4-(4-methylphenyl)butan-2-amine

生成物 1

HCID 23322177N-(3-(4-Methylphenyl)-1,1-dimethylpropyl)-2-hydroxy-2-(3-chlorophenyl)ethanamine

実験手順

The title compound was prepared in the manner described in Example 9 using 3-chlorophenylglyoxal and 3-(4-methylphenyl)-1,1-dimethylpropanamine. The chromatographed material was recrystallized from cyclohexane to give the title compound m.p. 136. τ(CDCL3 +d6DMSO) 8.9 (6H, s), 8.2-8.4 (2H, m), 7.7 (3H, s), 7.0-7.6 (4H, m), 5.35 (1H, dd), 2.9 (4H, s), 2.5-2.7 (5H, m).

後処理

  1. customThe title compound was prepared in the manner
  2. customThe chromatographed material was recrystallized from cyclohexane

出典と根拠

ORDレコード
ord-2d8e56e2bf444a0ab85fdddb57b92ca8
出典データセット
uspto-grants-1986_05
特許番号
US04588749

関連ノート

読み込み中…