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2-(3-Chlorophenyl)-2-oxoacetaldehyde → N-(3-(4-Methylphenyl)-1,1-dimethylpropyl)-2-hydroxy-2-(3-chlorophenyl)ethanamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(3-Chlorophenyl)-2-oxoacetaldehyde | HCID 12463893 | — |
| 反応物 | 2-Methyl-4-(4-methylphenyl)butan-2-amine | HCID 23322167 | — |
| 生成物 | N-(3-(4-Methylphenyl)-1,1-dimethylpropyl)-2-hydroxy-2-(3-chlorophenyl)ethanamine | HCID 23322177 | — |
反応手順
The title compound was prepared in the manner described in Example 9 using 3-chlorophenylglyoxal and 3-(4-methylphenyl)-1,1-dimethylpropanamine. The chromatographed material was recrystallized from cyclohexane to give the title compound m.p. 136. τ(CDCL3 +d6DMSO) 8.9 (6H, s), 8.2-8.4 (2H, m), 7.7 (3H, s), 7.0-7.6 (4H, m), 5.35 (1H, dd), 2.9 (4H, s), 2.5-2.7 (5H, m).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04588749 |
| 出典データセット | uspto-grants-1986_05 |
| ORD ID | ord-2d8e56e2bf444a0ab85fdddb57b92ca8 |
| 出典メモ | uspto-grants-1986_05 |