Water → p-Methylphenethylamine

HRID 280325

反応式

HRID 280325 の反応式
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][C:7]#[N:8])=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>CCOCC>[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][NH2:8])=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 962Water2 回HCID 14798Sodium HydroxideHCID 76280p-TolylacetonitrileHCID 21226445Aluminium lithium hydride

生成物 1

HCID 76751p-Methylphenethylamine収率 112.4%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

4-Methylbenzyl cyanide (10 g) in ether was added dropwise under nitrogen to lithium aluminium hydride (2.9 g) in ether. The solution was refluxed for 1 h at the end of addition. The reaction mixture was cooled, water (3 ml), 2N.NaOH (3 ml), and further water (9 ml) were added, the reaction mixture filtered, the residue washed with chloroform and the combined solvents dried (MgSO4). Evaporation gave 2-(4-methylphenyl)ethanamine (11.59 g).

後処理

  1. temperatureThe solution was refluxed for 1 h at the end of addition
  2. temperatureThe reaction mixture was cooled
  3. filtrationthe reaction mixture filtered
  4. washthe residue washed with chloroform
  5. dry with materialthe combined solvents dried (MgSO4)
  6. customEvaporation

出典と根拠

ORDレコード
ord-8d346d46b6794136a0e86b9fa123deeb
出典データセット
uspto-grants-1986_05
特許番号
US04588749

関連ノート

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