Acetone → 3H,5H-Pyrrolo[1,2-c]oxazol-5-one, tetrahydro-3,3-dimethyl-, (R)-

HRID 280384

反応式

HRID 280384 の反応式
[OH:1][CH2:2][CH:3]1[NH:7][C:6](=[O:8])[CH2:5][CH2:4]1.[CH3:9][C:10]([CH3:12])=O.C1(C)C=CC(S(O)(=O)=O)=CC=1.O>C1C=CC=CC=1>[CH3:9][C:10]1([CH3:12])[N:7]2[C:6](=[O:8])[CH2:5][CH2:4][C@@H:3]2[CH2:2][O:1]1

参加物

6

反応物 4

HCID 180AcetoneHCID 962WaterHCID 6101p-Toluenesulfonic acidHCID 5583595-(Hydroxymethyl)pyrrolidin-2-one

生成物 1

HCID 137469293H,5H-Pyrrolo[1,2-c]oxazol-5-one, tetrahydro-3,3-dimethyl-, (R)-

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

A mixture of 5-hydroxymethyl-2-pyrrolidone (0.4 g), acetone (5 ml) and p-toluenesulfonic acid (ca. 10 mg) was refluxed in 20 ml of benzene for 20 hours with a Dean-Stark water separator. After working up the reaction mixture, distillation (boiling point 70°-75° C. at 0.5 mm of Hg) yielded 0.2 g or (R)-tetrahydro-3,3-dimethyl-3H,5H-pyrrolo[1,2-c]oxazol-5-one as an oil.

後処理

  1. distillationthe reaction mixture, distillation (boiling point 70°-75° C. at 0.5 mm of Hg)

出典と根拠

ORDレコード
ord-e991fbdb9fa44be2826b25a00e89b6e8
出典データセット
uspto-grants-1986_05
特許番号
US04588819

関連ノート

読み込み中…