2-Methoxyaniline → HCID 23338370、化合物

HRID 28039ノート

反応式

HRID 28039 の反応式
[CH3:1][O:2][C:3]1[CH:9]=[CH:8][CH:7]=[CH:6][C:4]=1[NH2:5].C(=O)([O-])[O-].[Na+].[Na+].Br[CH2:17][CH:18]1[O:22][CH:21]([CH2:23][CH2:24][CH3:25])[CH2:20][O:19]1>>[CH2:23]([CH:21]1[CH2:20][O:19][CH:18]([CH2:17][NH:5][C:4]2[CH:6]=[CH:7][CH:8]=[CH:9][C:3]=2[O:2][CH3:1])[O:22]1)[CH2:24][CH3:25]

参加物

4

反応物 3

HCID 70002-MethoxyanilineHCID 10340Sodium CarbonateHCID 233383912-Bromomethyl-4-propyl-1,3-dioxolane

生成物 1

HCID 23338370HCID 23338370、化合物

実験手順

2-Methoxyaniline (0.05 mole) and sodium carbonate (30 grams) are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. 2-Bromomethyl-4-propyl-1,3-dioxolane (0.55 mole) is slowly added and the reaction mixture is heated at reflux for a period of about 1 hour. After this time the reaction mixture is filtered and additional sodium carbonate (5 grams) is added to the filtrate. The mixture is then distilled under reduced pressure to yield the desired product N-(4-propyl-1,3-dioxolan-2-ylmethyl)-2-methoxyaniline.

後処理

  1. customequipped with a mechanical stirrer
  2. temperaturethermometer and reflux condenser
  3. temperaturethe reaction mixture is heated
  4. temperatureat reflux for a period of about 1 hour
  5. filtrationAfter this time the reaction mixture is filtered
  6. additionadditional sodium carbonate (5 grams) is added to the filtrate
  7. distillationThe mixture is then distilled under reduced pressure

出典と根拠

ORDレコード
ord-24d24d89ab8b4c48a8a7cd14df8e53d6
出典データセット
uspto-grants-1980_09
特許番号
US04225335

反応ノート

読み込み中…