Sodium Carbonate → N-(4,5-dimethyl-1,3-dioxolan-2-ylmethyl)-2-n-butoxyaniline

HRID 28044

反応式

HRID 28044 の反応式
[CH2:1]([O:5][C:6]1[CH:12]=[CH:11][CH:10]=[CH:9][C:7]=1[NH2:8])[CH2:2][CH2:3][CH3:4].C(=O)([O-])[O-].[Na+].[Na+].Br[CH2:20][CH:21]1[O:25][CH:24]([CH3:26])[CH:23]([CH3:27])[O:22]1>>[CH3:27][CH:23]1[CH:24]([CH3:26])[O:25][CH:21]([CH2:20][NH:8][C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=2[O:5][CH2:1][CH2:2][CH2:3][CH3:4])[O:22]1

参加物

4

反応物 3

HCID 10340Sodium CarbonateHCID 1382652-ButoxyanilineHCID 128944572-Bromomethyl-4,5-dimethyl-1,3-dioxolane

生成物 1

HCID 23338378N-(4,5-dimethyl-1,3-dioxolan-2-ylmethyl)-2-n-butoxyaniline

反応条件

温度
100 °C

実験手順

2-n-Butoxyaniline (99 grams; 0.6 moles) and sodium carbonate (31.6 grams) were charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. 2-Bromomethyl-4,5-dimethyl-1,3-dioxolane (25 ml) was added and the reaction mixture was heated at a temperature of about 100° C. for a period of about 4 hours. After this time the reaction mixture was filtered and additional sodium carbonate (5.0 grams) was added to the filtrate. The mixture was then vacuum distilled and the fraction boiling at 123° C. and 0.05 mm of Hg pressure was collected to yield the desired product N-(4,5-dimethyl-1,3-dioxolan-2-ylmethyl)-2-n-butoxyaniline.

後処理

  1. customequipped with a mechanical stirrer
  2. temperaturethermometer and reflux condenser
  3. filtrationAfter this time the reaction mixture was filtered
  4. additionadditional sodium carbonate (5.0 grams) was added to the filtrate
  5. distillationvacuum distilled
  6. customthe fraction boiling at 123° C. and 0.05 mm of Hg pressure was collected

出典と根拠

ORDレコード
ord-0eabac01f602400795b8517efba6e5fe
出典データセット
uspto-grants-1980_09
特許番号
US04225335

関連ノート

読み込み中…