Tetrahydrofuran → HCID 178467483、化合物
反応式
C([N:4]1[CH:8]=[C:7]([CH3:9])[N:6]=[CH:5]1)(=O)C.[O:10]1CC[CH2:12][CH2:11]1>>[C:11]([C:8]1[NH:4][CH:5]=[N:6][C:7]=1[CH3:9])(=[O:10])[CH3:12]参加物
3
実験手順
A solution of 5.0 g (40.3 mmol) of 1-acetyl-4-methylimidazole in 700 ml of dry tetrahydrofuran was photolyzed in a quartz flask with a short wave ultraviolet light source (254 nm) for 24 hours. The tetrahydrofuran solution was concentrated in vacuo to give an oil which was chromatographed on silica gel using 5% methanol in chloroform as eluent to give 1.91 g (38%) of 5-acetyl-4-methylimidazole as a white solid, mp 140°-142°. nmr (CDCl3 /D6DMSO) (δ): 7.45 (s, 1H); 2.52 (s, 3H); 2.48 (s, 3H).
後処理
- concentrationThe tetrahydrofuran solution was concentrated in vacuo
- customto give an oil which
- customwas chromatographed on silica gel using 5% methanol in chloroform as eluent
出典と根拠
- ORDレコード
- ord-bca22a412c1d487ba3d9f14805accf3d
- 出典データセット
- uspto-grants-1986_05
- 特許番号
- US04590299
反応ノート
読み込み中…