Potassium Iodide → Ethyl 2-(p-chlorobenzylthio)-propionate
反応式
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][SH:7])=[CH:4][CH:3]=1.Br[CH:11]([CH3:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CC(C)=O>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][S:7][CH:11]([CH3:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:4][CH:3]=1参加物
6
実験手順
A mixture of 19.5 ml (0.15 mol) of 4-chlorobenzylmercaptan, 27.1 g (0.15 mol) of ethyl α-bromopropionate, 21 g of potassium carbonate and 0.1 g of potassium iodide in 100 ml of anhydrous acetone is kept under reflux for 6 hrs. It is filtered, the precipitate is washed with acetone and the filtrate is evaporated in vacuo. 200 ml of ether are added to the residue and the mixture is washed with dilute NaOH, dilute HCl and water, dried and evaporated in vacuo.
後処理
- temperatureunder reflux for 6 hrs
- filtrationIt is filtered
- washthe precipitate is washed with acetone
- customthe filtrate is evaporated in vacuo
- addition200 ml of ether are added to the residue
- washthe mixture is washed with dilute NaOH, dilute HCl and water
- customdried
- customevaporated in vacuo
出典と根拠
- ORDレコード
- ord-79fdbedb1756458194ee5fb490ea8b67
- 出典データセット
- uspto-grants-1980_09
- 特許番号
- US04225617
反応ノート
読み込み中…