Hydrochloric Acid → 1-(3-Furyl)-1-(4-methyl-5-oxazolyl)ethene

HRID 2820

反応式

HRID 2820 の反応式
[O:1]1[CH:5]=[CH:4][C:3]([C:6]([C:9]2[O:13][CH:12]=[N:11][C:10]=2[CH3:14])(O)[CH3:7])=[CH:2]1.Cl.C(OCC)C.C(=O)([O-])O.[Na+]>C(Cl)(Cl)Cl>[O:1]1[CH:5]=[CH:4][C:3]([C:6]([C:9]2[O:13][CH:12]=[N:11][C:10]=2[CH3:14])=[CH2:7])=[CH:2]1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 516892Sodium BicarbonateHCID 97941531-(3-Furyl)-1-(4-methyl-5-oxazolyl)ethanol

生成物 1

HCID 189362911-(3-Furyl)-1-(4-methyl-5-oxazolyl)ethene

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

1-(3-Furyl)-1-(4-methyl-5-oxazolyl)ethanol (900 mg) in dry chloroform was treated with 1M anhydrous hydrogen chloride in diethylether (1.1 equivalents). After 10 minutes at room temperature, aqueous sodium hydrogen carbonate was added and the mixture was extracted with dichloromethane. The material thus obtained was purified by flash chromatography to give the title compound as an almost colourless liquid.

後処理

  1. extractionthe mixture was extracted with dichloromethane
  2. customThe material thus obtained
  3. customwas purified by flash chromatography

出典と根拠

ORDレコード
ord-f8ae87d4cdb04743b3be2fcbfdc05511
出典データセット
uspto-grants-1998_03
特許番号
US05731335

関連ノート

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