Benzene → 2,4-Difluoro-1,1'-biphenyl

反応式

N(OCCC(C)C)=O.[F:9][C:10]1[CH:16]=[C:15]([F:17])[CH:14]=[CH:13][C:11]=1N.[CH:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[F:9][C:10]1[CH:16]=[C:15]([F:17])[CH:14]=[CH:13][C:11]=1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

参加物

反応物 3

HCID 241Benzene

HCID 8053Isoamyl Nitrite

HCID 97092,4-Difluoroaniline

生成物 1

HCID 1699742,4-Difluoro-1,1'-biphenyl

実験手順

To a 50 liter resin pot equipped with stirrer, thermometer, nitrogen-inlet, internal steam coil and reflux condenser is charged 31.5 liters of benzene, 1.025 liters of isoamyl nitrite and 700 g. (5.43 moles) of 2,4-difluoroaniline.

後処理

temperaturethermometer, nitrogen-inlet, internal steam coil and reflux condenser

出典と根拠

ORDレコード: ord-5307c143db8741daaf361f694bcedaa7
出典データセット: uspto-grants-1980_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04225730

反応ノート

読み込み中…