Hydrochloric Acid → 2',4'-Difluoro(1,1'-biphenyl)-4-ol
反応式
[OH-:1].[Na+].[F:3][C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:5]=1[C:11]1[CH:16]=[CH:15][C:14](CC([O-])=O)=[CH:13][CH:12]=1.Cl>O>[F:3][C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:5]=1[C:11]1[CH:16]=[CH:15][C:14]([OH:1])=[CH:13][CH:12]=1参加物
5
実験手順
A 30 liter resin pot is fitted with stirrer, thermometer and reflux condenser, and charged with 2.62 kg. of 50% aqueous sodium hydroxide and 11.34 liters of water. 4-(2',4'-Difluorophenyl)phenylacetate (1.876 kg., 7.55 m) is added and the batch is heated to reflux over 2.5 hours. The batch is refluxed for 2 hours (in solution at 75°), then cooled to 100° and added to a solution of 3.27 liters of concentrated hydrochloric acid in 9.8 liters of water in a 50 liter resin pot over a 30 minute period.
後処理
- temperaturethermometer and reflux condenser
- additioncharged with 2.62 kg
- temperaturethe batch is heated
- temperatureto reflux over 2.5 hours
- temperatureThe batch is refluxed for 2 hours (in solution at 75°)
- temperaturecooled to 100°
出典と根拠
- ORDレコード
- ord-dc15e23bc8184272bff1e209a9457cc9
- 出典データセット
- uspto-grants-1980_09
- 特許番号
- US04225730
反応ノート
読み込み中…