Hydroquinone → 4-(6-(2-Tetrahydropyranyl)oxyhexyloxy)phenol

HRID 28312

反応式

HRID 28312 の反応式
Cl[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][O:10]1.[C:15]1([CH:22]=[CH:21][C:19]([OH:20])=[CH:18][CH:17]=1)[OH:16].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>O.CS(C)=O>[O:10]1[CH2:11][CH2:12][CH2:13][CH2:14][CH:9]1[O:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][O:16][C:15]1[CH:22]=[CH:21][C:19]([OH:20])=[CH:18][CH:17]=1

参加物

7

反応物 4

HCID 785HydroquinoneHCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 3298032-(6-Chlorohexyloxy)tetrahydro-2H-pyran

生成物 1

HCID 178385764-(6-(2-Tetrahydropyranyl)oxyhexyloxy)phenol収率 82.5%

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 962Water溶媒

実験手順

A mixture of 10 g of 2-(6-chlorohexyloxy)tetrahydropyrane, 25 g of hydroquinone, 31 g of potassiumcarbonate, 0.752 g of potassiumiodide and 250 ml of dimethylsulfoxide was allowed to react for 4 days at 80° C. Subsequently, the reaction mixture was cooled to room temperature and after addition of water extracted with ether. The organic phase was then dried over sodium sulphate, filtered and concentrated to dryness. Chromatography on silica with 10% ethylacetate in toluene gave 11 g of product as a yellowish oil.

後処理

  1. customto react for 4 days at 80° C
  2. extractionextracted with ether
  3. dry with materialThe organic phase was then dried over sodium sulphate
  4. filtrationfiltered
  5. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-7f83b244a5014c8fbe2f48fda79a83a5
出典データセット
uspto-grants-2008_09
特許番号
US07419620B2

関連ノート

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