Furfurylamine → 2-Amino-3-cyano-4-furfurylaminoquinoline
反応式
[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH2:15]([NH2:21])[C:16]1[O:20][CH:19]=[CH:18][CH:17]=1>O>[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10]([NH:21][CH2:15][C:16]2[O:20][CH:19]=[CH:18][CH:17]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1参加物
4
実験手順
10 g of 2-amino-3-cyano-4-chloroquinoline is heated with 19 g of furfurylamine at 120° C. for 3 hours. The reaction mixture is cooled to 25 C. and mixed 6 times with 50 ml of water. The crystals are filtered off and dried. The resulting product is recrystallized from 60 ml of N,N-dimethylformamide, to obtain 5.8 g of the title compound, m.p.: 206° C.
後処理
- temperatureThe reaction mixture is cooled to 25 C
- filtrationThe crystals are filtered off
- customdried
- customThe resulting product is recrystallized from 60 ml of N,N-dimethylformamide
出典と根拠
- ORDレコード
- ord-5bda3d78ea3743e7a3af617fb0032deb
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07419977B2
反応ノート
読み込み中…