Trifluoroacetic acid → (4R)-4,8-Dimethylnonanoic acid

HRID 28447

反応式

HRID 28447 の反応式
C([O:5][C:6](=[O:17])[CH2:7][CH2:8][C@H:9]([CH3:16])[CH2:10][CH2:11][CH2:12][CH:13]([CH3:15])[CH3:14])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:16][C@H:9]([CH2:10][CH2:11][CH2:12][CH:13]([CH3:15])[CH3:14])[CH2:8][CH2:7][C:6]([OH:17])=[O:5]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 71406104tert-butyl (4R)-4,8-dimethylnonanoate

生成物 1

HCID 71351570(4R)-4,8-Dimethylnonanoic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

(4R)-4,8-dimethyl nonanoic acid t-butyl ester in 25 mL CH2Cl2 at 0° C. was treated with TFA (6 mL). The mixture was allowed to reach ambient temperature and stir overnight. The solvent was removed by rotary evaporation, and the mixture was purified by silica gel chromatography (95/5 hexane/EtOAc) to give 0.962 g (4R)-4,8-dimethyl nonanoic acid. m/z 185 (M−).

後処理

  1. customto reach ambient temperature
  2. customThe solvent was removed by rotary evaporation
  3. customthe mixture was purified by silica gel chromatography (95/5 hexane/EtOAc)

出典と根拠

ORDレコード
ord-6857fd771a8b44e0b17585c5501f4bf0
出典データセット
uspto-grants-2008_09
特許番号
US07419981B2

関連ノート

読み込み中…