3-Hydroxybenzaldehyde → 2-Chloro-3-hydroxybenzaldehyde
反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6].C(O[Cl:15])(C)(C)C>CC(O)=O>[Cl:15][C:3]1[C:2]([OH:1])=[CH:9][CH:8]=[CH:7][C:4]=1[CH:5]=[O:6]参加物
4
実験手順
To a suspension of 3-hydroxybenzaldehyde (20.12 g, 160 mmol) in HOAc (40 mL) was added carefully tBuOCl (20 mL, 176 mmol) with stirring. The reaction became a clear solution and strongly exothermic. It was allowed to cool and stirred for 16 hours, resulting in a white precipitate. The solid was filtered, washed with H2O and dried to give 2-chloro-3-hydroxybenzaldehyde (13.77 g, 55%), GCMS (EI) m/z 156, 158 (M+).
後処理
- temperatureto cool
- stirringstirred for 16 hours
- customresulting in a white precipitate
- filtrationThe solid was filtered
- washwashed with H2O
- customdried
出典と根拠
- ORDレコード
- ord-1a18f9f73569446985b955cf53886dc5
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07419983B2
反応ノート
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