Dimethylamine → Dimethylacetoacetamide

HRID 2851

反応式

HRID 2851 の反応式
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.CC(C)=O.[CH3:11][NH:12][CH3:13]>C1(C)C=CC=CC=1>[CH3:11][N:12]([CH3:13])[C:4](=[O:5])[CH2:3][C:2](=[O:6])[CH3:1]

参加物

4

反応物 2

HCID 674DimethylamineHCID 87118046Diketene acetone

生成物 1

HCID 16278Dimethylacetoacetamide

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of 9 ml (0.05 mmol) of diketene-acetone adduct in 20 ml of toluene was treated with gaseous dimethylamine at room temperature until the reaction was complete. The solvent was removed in vacuo and the residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→10%) yielding 7.0 g of the title compound.

後処理

  1. customThe solvent was removed in vacuo
  2. customthe residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→10%)

出典と根拠

ORDレコード
ord-eb592b1203c74e969732293b7513ee02
出典データセット
uspto-grants-1998_03
特許番号
US05731322

関連ノート

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