Sodium Hydroxide → HCID 178418482、化合物

HRID 2853

反応式

HRID 2853 の反応式
[O:1]=[C:2]([CH3:7])[CH2:3][C:4]([NH2:6])=[O:5].[OH-].[Na+].[Cl-].[C:11]1([N+:17]#[N:18])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>O>[C:11]1([NH:17][N:18]=[C:3]([C:2](=[O:1])[CH3:7])[C:4]([NH2:6])=[O:5])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 60992Benzenediazonium chlorideHCID 80077Acetoacetamide

生成物 1

HCID 178418482HCID 178418482、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

5.0 g (0.049 mol) of 3-oxobutyramide, a solution of 6.9 g (0.171 mol) of NaOH in 75 ml of water and 0.051 mol of phenyldiazonium chloride were treated as described in preparation 8. The crude reaction mixture was purified by chromatography on silica gel(EtOAc) obtaining 3 g of the title compound which was used as such in the subsequent step. M.p.=146°-147° C.

後処理

  1. customas described in preparation 8
  2. customThe crude reaction mixture
  3. customwas purified by chromatography on silica gel(EtOAc) obtaining 3 g of the title compound which

出典と根拠

ORDレコード
ord-fa496a7ce126439c8a04c703ffcedc08
出典データセット
uspto-grants-1998_03
特許番号
US05731322

関連ノート

読み込み中…