Sodium Hydroxide → HCID 178418269、化合物

HRID 2854

反応式

HRID 2854 の反応式
[CH:1]([N:4]([CH:11]([CH3:13])[CH3:12])[C:5](=[O:10])[CH2:6][C:7](=[O:9])[CH3:8])([CH3:3])[CH3:2].[OH-].[Na+].[Cl-].[C:17]1([N+:23]#[N:24])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>O>[CH:11]([N:4]([CH:1]([CH3:2])[CH3:3])[C:5](=[O:10])[C:6](=[N:24][NH:23][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:7](=[O:9])[CH3:8])([CH3:13])[CH3:12]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 60992Benzenediazonium chlorideHCID 123185413-Oxo-N,N-di(propan-2-yl)butanamide

生成物 1

HCID 178418269HCID 178418269、化合物収率 68.2%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

7.0 g (0.038 mol) of N,N-diisopropyl-3-oxobutyramide, a solution of 5.3 g (0.133 mol) of NaOH in 58 ml of water and 0.04 mol of phenyldiazonium chloride were treated as described in preparation 8. The crude reaction mixture was purified by chromatography on silica gel (hexane/Et2O 95:5) obtaining 7.5 g of the title compound which was used as such in the subsequent step. M.p.=143°-145° C.

後処理

  1. customas described in preparation 8
  2. customThe crude reaction mixture
  3. customwas purified by chromatography on silica gel (hexane/Et2O 95:5)

出典と根拠

ORDレコード
ord-ee71b009ed3f4c28bab5abd1c42abd9d
出典データセット
uspto-grants-1998_03
特許番号
US05731322

関連ノート

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