Water → HCID 178418328、化合物

HRID 2855

反応式

HRID 2855 の反応式
[CH3:1][CH2:2][O:3][C:4]([CH2:6][C:7]([C:9]([F:12])([F:11])[F:10])=[O:8])=[O:5].CC(O[Na])=O.O.[Cl-].[C:20]1([N+:26]#[N:27])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C(O)C>[C:20]1([NH:26][N:27]=[C:6]([C:7](=[O:8])[C:9]([F:10])([F:11])[F:12])[C:4]([O:3][CH2:2][CH3:1])=[O:5])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

参加物

6

反応物 4

HCID 962WaterHCID 60992Benzenediazonium chlorideHCID 67793Ethyl 4,4,4-trifluoroacetoacetateHCID 178418247HCID 178418247、化合物

生成物 1

HCID 178418328HCID 178418328、化合物収率 60%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

7.3 ml (0.05 mol) of ethyl 3-oxo-4,4,4-trifluoroacetoacetate, 6 g (0.073 mol) of CH3COONa, 20 ml of water, 37.5 ml of ethanol and a solution of 0.05 mol of phenyldiazonium chloride were treated as described in preparation 2. The crude product was purified by chromatography on silica gel (hexane/Et2O 0%→25%) obtaining 8.65 g of the title compound. M.p.=78°-80° C.

後処理

  1. customas described in preparation 2
  2. customThe crude product was purified by chromatography on silica gel (hexane/Et2O 0%→25%)

出典と根拠

ORDレコード
ord-5378909b6f194efbaaaae9d5077f9d43
出典データセット
uspto-grants-1998_03
特許番号
US05731322

関連ノート

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