Ammonia → 6-Chloro-2-(5-chloro-2-methoxy-phenyl)-pyrimidin-4-yl-amine

HRID 28552ノート

反応式

HRID 28552 の反応式
[NH3:1].[Cl:2][C:3]1[CH:8]=[C:7](Cl)[N:6]=[C:5]([C:10]2[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:11]=2[O:17][CH3:18])[N:4]=1>O1CCCC1>[Cl:2][C:3]1[N:4]=[C:5]([C:10]2[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:11]=2[O:17][CH3:18])[N:6]=[C:7]([NH2:1])[CH:8]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 860043224,6-Dichloro-2-(5-chloro-2-methoxy-phenyl)-pyrimidine

生成物 1

HCID 865946016-Chloro-2-(5-chloro-2-methoxy-phenyl)-pyrimidin-4-yl-amine収率 71%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
0 °C

実験手順

A pressure bottle was charged with tetrahydrofuran (50 ml) and cooled to 0° C. Ammonia gas was passed through the tetrahydrofuran until saturated. To this solution was added 4,6-dichloro-2-(5-chloro-2-methoxy-phenyl)-pyrimidine (0.15 g, 0.52 mmol) and the mixture was heated at 75-80° C. for 18 hours. Evaporation of volatiles under reduced pressure provided the hydrochloride salt of 6-chloro-2-(5-chloro-2-methoxy-phenyl)-pyrimidin-4-yl-amine (0.10 g, 71%).

後処理

  1. temperaturethe mixture was heated at 75-80° C. for 18 hours
  2. customEvaporation of volatiles under reduced pressure

出典と根拠

ORDレコード
ord-97b39919a934456f93f9680b97547dc4
出典データセット
uspto-grants-2008_09
特許番号
US07419984B2

反応ノート

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