Dichloromethane → 5-Bromo-1-methyl-3-(1,2,3,4-tetrahydroisoquinolin-6-ylamino)pyrazin-2(1H)-one

反応式

[Br:1][c:2]1[cH:3][n:4]([CH3:27])[c:5](=[O:26])[c:6]([NH:8][c:9]2[cH:10][c:11]3[c:16]([cH:17][cH:18]2)[CH2:15][N:14]([C:19]([O:20][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:25])[CH2:13][CH2:12]3)[n:7]1.[CH2:35]([Cl:36])[Cl:37].[OH:28][C:29]([C:30]([F:31])([F:32])[F:33])=[O:34]>>[Br:1][c:2]1[cH:3][n:4]([CH3:27])[c:5](=[O:26])[c:6]([NH:8][c:9]2[cH:10][c:11]3[c:16]([cH:17][cH:18]2)[CH2:15][NH:14][CH2:13][CH2:12]3)[n:7]1

参加物

反応物 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 58044031tert-Butyl 6-(6-bromo-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)-3,4-dihydroisoquinoline-2(1H)-carboxylate

生成物 1

HCID 580437085-Bromo-1-methyl-3-(1,2,3,4-tetrahydroisoquinolin-6-ylamino)pyrazin-2(1H)-one

出典と根拠

ORDレコード: ord-2efd12117d5f43f1965cdb88e0a13d56
出典データセット: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…