Guanidine Hydrochloride → HCID 178431786、化合物
反応式
Cl.[NH2:2][C:3]([NH2:5])=[NH:4].[CH3:6][CH:7]([C:13](OCC)=[O:14])[C:8](OCC)=[O:9].C[O-].[Na+]>C(O)C>[NH2:4][C:3]1[N:5]=[C:8]([OH:9])[C:7]([CH3:6])=[C:13]([OH:14])[N:2]=1参加物
5
反応条件
- 温度
- 65 °C
実験手順
To a stirred mixture of guanidine hydrochloride (1.91 g, 20.0 mmol) and diethyl methylmalonate (3.48 g, 20.0 mmol) in ethanol (30 ml) was added sodium methoxide (2.7 g, 50.0 mmol, 25% in methanol) dropwise. The cloudy mixture was stirred at 60-70° C. for 16 hours. After evaporation of volatiles under reduced pressure, the residue was treated with 1.0 M hydrochloric acid until pH=2. Filtration and drying provided 2-amino-4,6-dihydroxy-5-methyl-pyrimidine (2.5 g, 90% yield) as a white powder.
後処理
- customAfter evaporation of volatiles under reduced pressure
- additionthe residue was treated with 1.0 M hydrochloric acid until pH=2
- filtrationFiltration
- customdrying
出典と根拠
- ORDレコード
- ord-1761c4aa3b9744399647612277241c1c
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07419984B2
反応ノート
読み込み中…