4-Chloroaniline → 6-(5-Chloro-2-ethoxy-phenyl)-N*4*-(4-chloro-phenyl)-pyrimidine-2,4-diamine

HRID 28572

反応式

HRID 28572 の反応式
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:9]=2[O:15][CH2:16][CH3:17])[N:5]=[C:4]([NH2:18])[N:3]=1.[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([NH2:26])=[CH:22][CH:21]=1>>[Cl:14][C:12]1[CH:11]=[CH:10][C:9]([O:15][CH2:16][CH3:17])=[C:8]([C:6]2[N:5]=[C:4]([NH2:18])[N:3]=[C:2]([NH:26][C:23]3[CH:24]=[CH:25][C:20]([Cl:19])=[CH:21][CH:22]=3)[CH:7]=2)[CH:13]=1

参加物

3

反応物 2

HCID 78124-ChloroanilineHCID 860043254-Chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine

生成物 1

HCID 111647276-(5-Chloro-2-ethoxy-phenyl)-N*4*-(4-chloro-phenyl)-pyrimidine-2,4-diamine収率 45%

実験手順

Following the method described in Example 53, 4-chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine and 4-chloro-phenylamine provided the title compound (45% yield). 1H NMR (DMSO-d6) δ 1.39 (t, 3H, J=6.9 Hz, CH3), 4.14 (q, 2H, J=6.5 Hz, CH2), 6.36 (s, 2H, NH2), 6.78 (s, 1H, Ar), 7.15 (d, 1H, J=8.9 Hz, Ar), 7.32 (d, 2H, J=8.9 Hz, Ar), 7.41 (dd, 1H, J=8.8, 2.8 Hz, Ar), 7.79 (d, 2H, J=8.9 Hz, Ar), 7.91 (d, 1H, J=2.8 Hz), 9.31 (s, 1H, NH).

出典と根拠

ORDレコード
ord-68270ca637df496c9d22e33fb2924a2e
出典データセット
uspto-grants-2008_09
特許番号
US07419984B2

関連ノート

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