Hydrochloric Acid → 4-Anilino-3-nitrobenzoic acid

HRID 28663

反応式

HRID 28663 の反応式
F[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12].[NH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.Cl>C(O)C.O>[NH:14]([C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 6115AnilineHCID 679874-Fluoro-3-nitrobenzoic acid

生成物 1

HCID 38243664-Anilino-3-nitrobenzoic acid

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

4-Fluoro-3-nitrobenzoic acid (21.6 mmol) and an aniline (43.2 mmol) in 15 mL of ethanol were stirred at reflux under argon for 5 h resulting in the formation of an orange precipitate. After 12 h the heterogeneous reaction mixture was poured into 50 mL of 1N HCl(aq) and diluted with 100 mL of water. The solution was stirred for 20 min then the precipitate filtered to yield the 4-anilino-3-nitrobenzoic Acid: e.g. 4-{[3-(benzyloxy)phenyl]amino}-3-nitrobenzoic acid.

後処理

  1. temperatureat reflux under argon for 5 h
  2. customresulting in the formation of an orange precipitate
  3. filtrationthe precipitate filtered

出典と根拠

ORDレコード
ord-8ab56e89eb204695b2ea7c0c30ec3f5d
出典データセット
uspto-grants-2008_09
特許番号
US07419995B2

関連ノート

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