Hydrochloric Acid → (+/-)-trans-2-Diethylaminocarbonyl-6-(2-furylmethyl)-8a-(3-methoxyphenyl)-3-methyl-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrrolo[2,3-g]isoquinoline hydrochloride

HRID 2877

反応式

HRID 2877 の反応式
[CH2:1]([N:3]([CH2:28][CH3:29])[C:4]([C:6]1[NH:26][C:9]2[CH2:10][C@@:11]3([C:18]4[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH3:25])[CH:19]=4)[C@H:16]([CH2:17][C:8]=2[C:7]=1[CH3:27])[CH2:15][NH:14][CH2:13][CH2:12]3)=[O:5])[CH3:2].[O:30]1[CH:34]=[CH:33][CH:32]=[C:31]1[CH:35]=O.C([BH3-])#N.[Na+].[ClH:41]>CO.C(O)(=O)C>[ClH:41].[CH2:28]([N:3]([CH2:1][CH3:2])[C:4]([C:6]1[NH:26][C:9]2[CH2:10][C@@:11]3([C:18]4[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH3:25])[CH:19]=4)[C@H:16]([CH2:17][C:8]=2[C:7]=1[CH3:27])[CH2:15][N:14]([CH2:35][C:31]1[O:30][CH:34]=[CH:33][CH:32]=1)[CH2:13][CH2:12]3)=[O:5])[CH3:29]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 7362Furfural2 回HCID 5003444Sodium cyanoborohydride2 回HCID 22883692(+/-)-trans-2-diethylaminocarbonyl-8a-(3-methoxyphenyl)-3-methyl-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrrolo[2,3-g]isoquinoline

生成物 1

HCID 22883648(+/-)-trans-2-Diethylaminocarbonyl-6-(2-furylmethyl)-8a-(3-methoxyphenyl)-3-methyl-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrrolo[2,3-g]isoquinoline hydrochloride

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒2 回HCID 887Methanol溶媒

反応条件

温度
0 °C

実験手順

1.3 g (3.3 mmol) of (±)-trans-2-diethylaminocarbonyl-8a-(3-methoxyphenyl)-3-methyl-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrrolo[2,3-g]isoquinoline, 0.28 ml (4.95 mmol) of acetic acid, 0.33 ml (3.96 mmol) of 2-furaldehyde were dissolved in 50 ml of MeOH under nitrogen atmosphere. 0.415 g (6.6 mmol) of sodium cyanoborohydride were added and the solution stirred for 15 h. Additional acetic acid (0.1 ml), 2-furaldehyde (0.3 ml) and sodium cyanoborohydride (0.2 g) were added. After two hours of stirring the reaction mixture was cooled to 0° C. and 50 ml of 5N hydrochloric acid were added. The solvent was removed in vacuo, the aqueous solution was extracted with Et2O, the pH was adjusted to 8 with 20% NaOH and then extracted with AcOEt. The organic layer was dried over Na2SO4 and the solvent was removed in vacuo. The crude product was dissolved in acetone/MeOH and the solution brought to acidic pH with HCl/Et2O . The precipitate was filtered, yielding 1.7 g of the title compound. M.p.=105° C. dec.

後処理

  1. stirringAfter two hours of stirring the reaction mixture
  2. customThe solvent was removed in vacuo
  3. extractionthe aqueous solution was extracted with Et2O
  4. extractionextracted with AcOEt
  5. dry with materialThe organic layer was dried over Na2SO4
  6. customthe solvent was removed in vacuo
  7. dissolutionThe crude product was dissolved in acetone/MeOH
  8. filtrationThe precipitate was filtered

出典と根拠

ORDレコード
ord-cd9b39ec611d404d9a8ea9bc73cb12d3
出典データセット
uspto-grants-1998_03
特許番号
US05731322

関連ノート

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