Sulfuric Acid → HCID 20110268、化合物

HRID 28774ノート

反応式

HRID 28774 の反応式
C[CH:2]1[CH2:6][CH2:5][CH2:4][C:3]1([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[F:16])[C:7]([OH:9])=[O:8].S(=O)(=O)(O)O.[C:22](=O)([O-])[O-].[Na+].[Na+]>CO>[F:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[C:3]1([C:7]([O:9][CH3:22])=[O:8])[CH2:4][CH2:5][CH2:6][CH2:2]1

参加物

5

反応物 3

HCID 1118Sulfuric AcidHCID 10340Sodium CarbonateHCID 69250408Methyl 1-(2-fluorophenyl)cyclopentanecarboxylic acid

生成物 1

HCID 20110268HCID 20110268、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of methyl 1-(2-fluorophenyl)cyclopentanecarboxylic acid (5.0 g, 24.01 mmol) in anhydrous methanol was added 1 mL of the concentration of sulfuric acid. The mixture was refluxed for overnight. The mixture was neutralized to pH 4-5 with sodium carbonate. The solvent was evaporated. The residue was dissolved in ethyl acetate (50 mL), washed with brine (3×10 mL), dried over MgSO4. The crude product was used for the next reaction without further purification.

後処理

  1. temperatureThe mixture was refluxed for overnight
  2. customThe solvent was evaporated
  3. dissolutionThe residue was dissolved in ethyl acetate (50 mL)
  4. washwashed with brine (3×10 mL)
  5. dry with materialdried over MgSO4
  6. customThe crude product was used for the next reaction without further purification

出典と根拠

ORDレコード
ord-04cf99ab5d9c48e289c766d5829a0809
出典データセット
uspto-grants-2008_09
特許番号
US07419999B2

反応ノート

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