Sulfuric Acid → Methyl 1-(4-chlorophenyl)cyclobutane-1-carboxylate
反応式
C[CH:2]1[CH2:5][CH2:4][C:3]1([C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=1)[C:6]([OH:8])=[O:7].S(=O)(=O)(O)O.[C:21](=O)([O-])[O-].[Na+].[Na+]>CO>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([C:3]2([C:6]([O:8][CH3:21])=[O:7])[CH2:4][CH2:5][CH2:2]2)=[CH:10][CH:11]=1参加物
5
実験手順
To a solution of methyl 1-(4-chlorophenyl)cyclobutanecarboxylic acid (5.0 g, 23.73 mmol) in anhydrous methanol was added 1 mL of the concentration of sulfuric acid. The mixture was refluxed for overnight. The mixture was neutralized to pH 4-5 with sodium carbonate. The solvent was evaporated. The residue was dissolved in ethyl acetate (50 mL), washed with brine (3×10 mL), dried over MgSO4. The crude product was used for the next reaction without further purification.
後処理
- temperatureThe mixture was refluxed for overnight
- customThe solvent was evaporated
- dissolutionThe residue was dissolved in ethyl acetate (50 mL)
- washwashed with brine (3×10 mL)
- dry with materialdried over MgSO4
- customThe crude product was used for the next reaction without further purification
出典と根拠
- ORDレコード
- ord-a8e24215a21e4033b1e0210b40818937
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07419999B2
反応ノート
読み込み中…