Hydrochloric Acid → 4-(4-Ethylphenyl)-4-oxobutanoic acid

HRID 2886

反応式

HRID 2886 の反応式
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1)[CH3:2].[Cl-].[Al+3].[Cl-].[Cl-].[C:13]1(=[O:19])[O:18][C:16](=[O:17])[CH2:15][CH2:14]1.Cl>>[O:19]=[C:13]([C:6]1[CH:7]=[CH:8][C:3]([CH2:1][CH3:2])=[CH:4][CH:5]=1)[CH2:14][CH2:15][C:16]([OH:18])=[O:17]

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 7500EthylbenzeneHCID 7922Succinic anhydrideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 3169834-(4-Ethylphenyl)-4-oxobutanoic acid

実験手順

5 cm3 of ethylbenzene and 2.6 g of aluminum chloride are mixed with magnetic stirring in a 50-cm3 flask. The solution is cooled in an ice bath and 1 g of succinic anhydride is then added. The reaction mixture is stirred for 1 h 30 min at a temperature of 0° C. and then for 3 h at room temperature. It is poured into ice. The resulting mixture is acidified by adding 1N hydrochloric acid (pH 3-4). It is extracted with 3 volumes of ether. The organic phases are washed 3 times with 10% potassium carbonate solution. The aqueous phases are combined and acidified by adding concentrated hydrochloric acid. The precipitate obtained is drained and then recrystallized.

後処理

  1. temperatureThe solution is cooled in an ice bath
  2. stirringThe reaction mixture is stirred for 1 h 30 min at a temperature of 0° C.
  3. additionIt is poured into ice
  4. extractionIt is extracted with 3 volumes of ether
  5. washThe organic phases are washed 3 times with 10% potassium carbonate solution
  6. additionby adding concentrated hydrochloric acid
  7. customThe precipitate obtained
  8. customrecrystallized

出典と根拠

ORDレコード
ord-14978e6518ec43e492e5f892cd564bb7
出典データセット
uspto-grants-1998_03
特許番号
US05731352

関連ノート

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