Triethylsilane → 4-(4-Ethylphenyl)butanoic acid
反応式
C([SiH](CC)CC)C.O=[C:9]([C:15]1[CH:20]=[CH:19][C:18]([CH2:21][CH3:22])=[CH:17][CH:16]=1)[CH2:10][CH2:11][C:12]([OH:14])=[O:13]>FC(F)(F)C(O)=O>[CH2:21]([C:18]1[CH:19]=[CH:20][C:15]([CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[CH:16][CH:17]=1)[CH3:22]参加物
4
実験手順
In a 100-cm3 flask, 2.5 g of 4-oxo-4-(4-ethylphenyl)butyric acid are dissolved with magnetic stirring in 19 cm3 of trifluoroacetic acid. 3.2 g of triethylsilane are added dropwise. The reaction mixture is stirred for 86 hours at room temperature. It is poured into ice. It is extracted with 3 volumes of ether. The organic phases are washed 3 times with 10% potassium carbonate solution. The aqueous phases are combined and then acidified by adding concentrated hydrochloric acid until the pH is 3-4. The precipitate obtained is drained and then recrystallized.