Potassium Cyanide → 4-(7-Methoxy-1-naphthyl)butyronitrile
反応式
[C-:1]#[N:2].[K+].S(O[CH2:9][CH2:10][CH2:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[C:19]([O:22][CH3:23])[CH:20]=2)[CH:15]=[CH:14][CH:13]=1)(=O)(=O)C>CS(C)=O>[CH3:23][O:22][C:19]1[CH:20]=[C:21]2[C:16]([CH:15]=[CH:14][CH:13]=[C:12]2[CH2:11][CH2:10][CH2:9][C:1]#[N:2])=[CH:17][CH:18]=1参加物
4
実験手順
In a 100-cm3 flask, the 3-(7-methoxy-1-naphthyl)propyl mesylate obtained in stage D is dissolved in DMSO. KCN is added and the mixture is brought to reflux for 2 h. It is allowed to cool. It is poured into a water/ice mixture. The resulting mixture is extracted with ether. The organic phase is washed with water, dried over CaCl2 and evaporated. The product obtained is recrystallized.
後処理
- temperatureto reflux for 2 h
- temperatureto cool
- extractionThe resulting mixture is extracted with ether
- washThe organic phase is washed with water
- dry with materialdried over CaCl2
- customevaporated
- customThe product obtained
- customis recrystallized
出典と根拠
- ORDレコード
- ord-ebf01e6b38bc42c089b9940d05b2423f
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05731352
反応ノート
読み込み中…