Potassium Cyanide → 4-(7-Methoxy-1-naphthyl)butyronitrile

HRID 2888

反応式

HRID 2888 の反応式
[C-:1]#[N:2].[K+].S(O[CH2:9][CH2:10][CH2:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[C:19]([O:22][CH3:23])[CH:20]=2)[CH:15]=[CH:14][CH:13]=1)(=O)(=O)C>CS(C)=O>[CH3:23][O:22][C:19]1[CH:20]=[C:21]2[C:16]([CH:15]=[CH:14][CH:13]=[C:12]2[CH2:11][CH2:10][CH2:9][C:1]#[N:2])=[CH:17][CH:18]=1

参加物

4

反応物 2

HCID 9032Potassium CyanideHCID 153368673-(7-Methoxy-1-naphthyl)propyl mesylate

生成物 1

HCID 153368684-(7-Methoxy-1-naphthyl)butyronitrile

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

In a 100-cm3 flask, the 3-(7-methoxy-1-naphthyl)propyl mesylate obtained in stage D is dissolved in DMSO. KCN is added and the mixture is brought to reflux for 2 h. It is allowed to cool. It is poured into a water/ice mixture. The resulting mixture is extracted with ether. The organic phase is washed with water, dried over CaCl2 and evaporated. The product obtained is recrystallized.

後処理

  1. temperatureto reflux for 2 h
  2. temperatureto cool
  3. extractionThe resulting mixture is extracted with ether
  4. washThe organic phase is washed with water
  5. dry with materialdried over CaCl2
  6. customevaporated
  7. customThe product obtained
  8. customis recrystallized

出典と根拠

ORDレコード
ord-ebf01e6b38bc42c089b9940d05b2423f
出典データセット
uspto-grants-1998_03
特許番号
US05731352

関連ノート

読み込み中…