Ethyl Acetate → 2-Methyl-4-(4-nitrophenyl)thiazole

HRID 28938

反応式

HRID 28938 の反応式
Br[C:2]1[CH:3]=[C:4]([C:11](=O)[CH3:12])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[C:14]([NH2:17])(=[S:16])[CH3:15].C(OCC)(=O)C>CN(C)C=O>[CH3:15][C:14]1[S:16][CH:12]=[C:11]([C:4]2[CH:5]=[CH:6][C:7]([N+:8]([O-:10])=[O:9])=[CH:2][CH:3]=2)[N:17]=1

参加物

5

反応物 3

HCID 8857Ethyl AcetateHCID 2723949ThioacetamideHCID 12224159Agn-PC-0NI5CD

生成物 1

HCID 1936892-Methyl-4-(4-nitrophenyl)thiazole収率 80%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of 3-bromo-(4-nitrophenyl)-ethanone (2.5 mmol) and thioacetamide (3 mmol) in N,N-dimethylformamide (20 mL) was heated at 65° C. for 8 h. Ethyl acetate (40 mL) was added and the solution was washed with water (3×20 mL). The product was purified by crystallization from ether to give the title product (80%). ESMS [M+H]+: 221.2

後処理

  1. washthe solution was washed with water (3×20 mL)
  2. customThe product was purified by crystallization from ether

出典と根拠

ORDレコード
ord-536929d985b84098ae6f526d48854910
出典データセット
uspto-grants-2008_09
特許番号
US07419988B2

関連ノート

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