Ethyl Acetate → 2-Methyl-4-(4-nitrophenyl)thiazole
反応式
Br[C:2]1[CH:3]=[C:4]([C:11](=O)[CH3:12])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[C:14]([NH2:17])(=[S:16])[CH3:15].C(OCC)(=O)C>CN(C)C=O>[CH3:15][C:14]1[S:16][CH:12]=[C:11]([C:4]2[CH:5]=[CH:6][C:7]([N+:8]([O-:10])=[O:9])=[CH:2][CH:3]=2)[N:17]=1参加物
5
実験手順
A solution of 3-bromo-(4-nitrophenyl)-ethanone (2.5 mmol) and thioacetamide (3 mmol) in N,N-dimethylformamide (20 mL) was heated at 65° C. for 8 h. Ethyl acetate (40 mL) was added and the solution was washed with water (3×20 mL). The product was purified by crystallization from ether to give the title product (80%). ESMS [M+H]+: 221.2
後処理
- washthe solution was washed with water (3×20 mL)
- customThe product was purified by crystallization from ether
出典と根拠
- ORDレコード
- ord-536929d985b84098ae6f526d48854910
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07419988B2
反応ノート
読み込み中…