Bromine → 5-Bromo-2-methyl-4-(4-nitrophenyl)-1,3-thiazole

HRID 28939

反応式

HRID 28939 の反応式
[Br:1]Br.[CH3:3][C:4]1[S:5][CH:6]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=2)[N:8]=1>C(Cl)(Cl)Cl>[Br:1][C:6]1[S:5][C:4]([CH3:3])=[N:8][C:7]=1[C:9]1[CH:10]=[CH:11][C:12]([N+:15]([O-:17])=[O:16])=[CH:13][CH:14]=1

参加物

4

反応物 2

HCID 24408BromineHCID 1936892-Methyl-4-(4-nitrophenyl)thiazole

生成物 1

HCID 689981005-Bromo-2-methyl-4-(4-nitrophenyl)-1,3-thiazole収率 60%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Bromine (6 mmol) was added dropwise to a solution of 2-methyl-4-(4-nitrophenyl)-1,3-thiazole (5 mmol) in chloroform (20 mL) and the solution refluxed for 4 h. The solvent was evaporated and the product purified by crystallization from ether to afford the title compound (60%). ESMS [M+H]+: 300.2

後処理

  1. temperaturethe solution refluxed for 4 h
  2. customThe solvent was evaporated
  3. customthe product purified by crystallization from ether

出典と根拠

ORDレコード
ord-f568c5925b31445c930c80d3f993e376
出典データセット
uspto-grants-2008_09
特許番号
US07419988B2

関連ノート

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