Tetrahydrofuran → 4-(4-Bromo-2-fluorophenylamino)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid

反応式

[Br:6][c:7]1[cH:8][c:9]([F:14])[c:10]([NH2:13])[cH:11][cH:12]1.[CH2:27]1[O:28][CH2:29][CH2:30][CH2:31]1.[CH3:1][CH2:2][CH2:3][CH2:4][Li:5].[Cl:15][c:16]1[c:17]([C:24](=[O:25])[OH:26])[cH:18][n:19]([CH3:23])[c:20](=[O:22])[cH:21]1>>[Br:6][c:7]1[cH:8][c:9]([F:14])[c:10]([NH:13][c:16]2[c:17]([C:24](=[O:25])[OH:26])[cH:18][n:19]([CH3:23])[c:20](=[O:22])[cH:21]2)[cH:11][cH:12]1