Methyl iodide → 4-Methoxy-3,5-dimethyl-benzofuran-2-carboxylic acid tert-butyl ester

HRID 29424ノート

反応式

HRID 29424 の反応式
[C:1]([O:5][C:6]([C:8]1[O:9][C:10]2[CH:17]=[CH:16][C:15]([CH3:18])=[C:14]([OH:19])[C:11]=2[C:12]=1[CH3:13])=[O:7])([CH3:4])([CH3:3])[CH3:2].IC.[C:22]([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[C:1]([O:5][C:6]([C:8]1[O:9][C:10]2[CH:17]=[CH:16][C:15]([CH3:18])=[C:14]([O:19][CH3:22])[C:11]=2[C:12]=1[CH3:13])=[O:7])([CH3:4])([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 68707780HCID 68707780、化合物

生成物 1

HCID 687166394-Methoxy-3,5-dimethyl-benzofuran-2-carboxylic acid tert-butyl ester収率 97.3%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To 80 mg of 4-hydroxy-3,5-dimethyl-benzofuran-2-carboxylic acid tert-butyl ester was added 1 mL of iodomethane, 80 mg of K2CO3 and 1 mL of DMF. The mixture was stirred at room temperature overnight. The reaction mixture was washed with brine and extracted with ethyl acetate. The combined ethyl acetate solution was washed with brine. Removal of the solvent gave 82 mg of 4-methoxy-3,5-dimethyl-benzofuran-2-carboxylic acid tert-butyl ester as a pale yellow solid.

後処理

  1. washThe reaction mixture was washed with brine
  2. extractionextracted with ethyl acetate
  3. washThe combined ethyl acetate solution was washed with brine
  4. customRemoval of the solvent

出典と根拠

ORDレコード
ord-03cc3561d1534fcab575109e3b194a44
出典データセット
uspto-grants-2008_09
特許番号
US07420001B2

反応ノート

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