2-Amino-4-methylphenol → 5-Methyl-benzooxazole-2-carboxylic acid ethyl ester
反応式
[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[OH:9].[CH2:10]([O:12][C:13](OCC)([O:19]CC)[C:14](OCC)=O)[CH3:11]>>[CH2:10]([O:12][C:13]([C:14]1[O:9][C:3]2[CH:4]=[CH:5][C:6]([CH3:8])=[CH:7][C:2]=2[N:1]=1)=[O:19])[CH3:11]参加物
3
反応条件
- 温度
- 110 °C
実験手順
To 2-amino-4-methylphenol (1 g, 8.1 mmol) was added ethyl triethoxyacetate (5.4 g, 3 eq). The mixture was stirred at 110° C. overnight. The reaction mixture was cooled and triturated with hexane. Filtration gave 850 mg (91%) of 5-methyl-benzooxazole-2-carboxylic acid ethyl ester as a white solid.
後処理
- temperatureThe reaction mixture was cooled
- customtriturated with hexane
- filtrationFiltration
出典と根拠
- ORDレコード
- ord-8b7b0d44b47645e18d89b4e26aef221a
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07420001B2
反応ノート
読み込み中…